microcrystalline cellulose msds fmc

We can send by Fedex, by ship or by plane according to international rules. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. SUBSTANCE IDENTIFICATION 1.1. <> 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W These grades have particle sizes ranging from <30 to approximately 200. 9,LL!z BIOACCUMULATIVE POTENTIAL No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. . Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Some substance identifiers may have been claimed confidential, or may . Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. We are artists at heart and creators by nature. w !1AQaq"2B #3Rbr . <> Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Learn about FMC's industry leading goal of net-zero emissions by 2035. PharmaCentral 2021 . P}MFbN#[>r(y iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. CAS #: 9004-34-6 1.3. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Micro Crystalline Cellulose. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Microcrystalline Cellulose Side Effects. %PDF-1.4 The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. PDF (28.38 mb) 2022 Corporate Fact Sheet. % Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Manufacturer: FMC BioPolymer. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Production of Pharmaceutical Grade Microcrystalline Cellulose. Chemical Formula: (C6H10O5)n 1.4. 4 0 obj This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . The aqueous solution to barrier membrane coating. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. INCI. Product Name: Microcrystalline Cellulose E460 1.2. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Avicel RC-591 & CL-611 - Description. MSDS Ref. However, consumption of large quantities of the material may have a laxative effect. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. By producing Avicel . Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm xv}O2' H~KEe9>G/,:9\i : CL-611NF Date Approved: 01/13/2010. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Explore how we work and why we apply science and creativity for a better world to everything we do. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. All rights reserved. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. % q9;v80q>jZ A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Microcrystalline Cellulose E460 MSDS 1. (&E. Gloves, eye protection and a dust mask should be used. 1. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) It is . However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Microcrystalline Cellulose (MCC) MSDS 1. q86@on$^X_HuH;3` JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Delivering efficient and robust formulations. Document(s): certificate data msds. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Cellulose microcrystalline for column chromatography. Avicel Microcrystalline Cellulose: Chemical Identifiers. Trademarks: Avicel PH-102. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. /Resources 2 0 R Microcrystalline Cellulose (MCC) Manufacturing Industry. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Avicel PH-200 microcrystalline cellulose NF, Ph. If you are already a ChemPoint customer then sign up for access to our online ordering website. SDS. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . /Contents 4 0 R The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. FMC Corporation. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Avicel Microcrystalline Cellulose Physical Properties. PDF (2.77 mb) 2021 FMC Sustainability Report. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) The table below shows the most common physicochemical parameters of this raw material. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. (Microcrystalline Cellulose Market Pr. Avicel PH-101. MATERIAL SAFETY DATA SHEET Version: 1.0 1. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. EINECS #: 232-674-9 1.7. LOT #: Available upon request. Cellulose microcrystalline. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. ( Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. However, it yields non-digestible fibre. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Avicel PC 611 (FMC Biopolymer) . FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . 0.25 - 0.37. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. CAS 9004-34-6. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. No. l~5C Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. The most. %PDF-1.5 X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . CAS #: 9004-34-6 . Truly distinctive drug delivery solutions. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. It is also used in plaque assays for counting. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Remove We know that our customers need to provide reliable and consistent products to their patients. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Home. Packaging: 34 x 50 kgs fiber drums. cas:9000-11-7 msds Carboxymethyl cellulose. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream CoA. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Earth Supplied Products LLC. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. The short-term limit for total inhalable dust is 20 mg/m3. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. SCMm_>x^O9l (n. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P High performance lubricant that brings more to the tablet.

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